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Title 

Antidiabetic effects of extracts from Psidium guajava

Authors 

Won Keun OhChul Ho LeeMyung Sun LeeEun Young BaeC B SohnHyuncheol OhBo Yeon KimJong Seog Ahn

Publisher 

Elsevier

Issue Date 

2005

Citation 

Journal of Ethnopharmacology, vol. 96, no. 3, pp. 411-415

Keywords 

blood glucoseLeprdb/Leprdb micepsidium guajavaPTP1Btype 2 diabetesplant extractantidiabetic agentplant extractspsidium

Abstract 

During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Leprdb/Leprdb mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Leprdb/Leprdb mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Leprdb/Lepr db mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2004.09.041

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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