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Title 

Evolution of microRNAs located within Hox gene clusters

Authors 

A TanzerC T AmemiyaChang-Bae KimP F Stadler

Issue Date 

2005

Citation 

Journal of Experimental Zoology, vol. 304B, no. 1, pp. 75-85

Keywords 

evolutiongene expression regulationgenetic transcriptiongeneticsmolecular geneticsmultigene familygenes, homeoboxmicroRNAs

Abstract 

MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in post-transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss.

ISSN 

0022-104X

Link 

http://dx.doi.org/10.1002/jez.b.21021

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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