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Title 

In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Authors 

Y C KimHyuncheol OhBeom Seok KimT H KangE K KoYu Mi HanBo Yeon KimJong Seog Ahn

Publisher 

Georg Thieme Verlag

Issue Date 

2005

Citation 

Planta Medica, vol. 71, no. 1, pp. 87-89

Keywords 

corylininsulinphenol derivativeprotein tyrosine phosphatase 1Bpsoralidinenzyme inhibitionin vitro studyinsulin sensitivitykineticsplant seed

Abstract 

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2005-837759

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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