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Title 

(E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors

Authors 

Tae Sook JeongMi Jeong KimHana YuKyung Soon KimJ K ChoiS S KimWoo Song Lee

Publisher 

Elsevier

Issue Date 

2005

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 5, pp. 1525-1527

Keywords 

Lp-PLA2 inhibitorlipoproteinoxime derivativephospholipase A2 inhibitorenzyme inhibitorsoximesphospholipases A

Abstract 

A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2004.11.063

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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