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Title 

Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice

Authors 

Ai-Guo WangH B MoonY H LeeSeong Lan YuHyun Jung KwonY H HanW FangT H LeeK L JangS K KimDae Yeul YuDong Seok Lee

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2004

Citation 

Experimental and Molecular Medicine, vol. 36, no. 6, pp. 588-593

Keywords 

coredysplasiahepatitis C virustransgenic micecore proteinanimal cellcontrolled studycytopathogenic effectdisease coursegene expression

Abstract 

Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are cytopathic to liver, three types of transgenic mice were established. The expression of transgenes was confirmed by HCV specific RT-PCR and Western immunoblotting. The livers of all wild type core and S116I transgenic lineages remained largely histologically normal. However, the livers of the S99Q transgenic mice showed significant high level of cell dysplasia associated with the transgene expression in hepatocytes largely located around the central veins by in situ hybridization analysis. In conclusion, the mutant HCV core protein at S99Q may contribute to the progress of HCV induced liver disease.

ISSN 

1226-3613

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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