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Title 

Protein kinases as pharmacological targets for the reduction of interleukin-1 expression in lipopolysaccaride-activated primary glial cell

Authors 

H N SunW FangM H JinY H HanSun-Uk KimS H LeeNam-Soon KimCheol Hee KimDong Seok Lee

Issue Date 

2004

Citation 

Korean Journal of Biomedical Laboratory Science, vol. 10, no. 4, pp. 325-332

Keywords 

glial cellmicrogliainterleukin-1neuroinflammation

Abstract 

Inflammatory factor such as Interleukin-1 play important roles in determining the fate of both acute and chronic neurological disorders. We investigated whether inhibitors of PKC or PTK can serve as pharmacological agents to reduce IL-1 production and the mechanisms underlying their pharmacological effects in a mixed population of glia. Inhibitors of PKC such as H7, Go6976 and Ro31-8220 significantly reduced both the mRNA and protein levels of IL-1α and IL-β in lipopolysaccharide-activated primary glial cells. While the PTK inhibitor genistein also significantly reduced the production of these cytokines, it did not affect the expression of their mRNA. Taken together, inhibitors of PKC and PTK could serve as pharmacological agents to reduce IL-1 production. However, the mechanisms underlying their pharmacological effects are different. Our results provide evidence that inhibitors of protein kinases can serve as pharmacological agents to modulate IL-1 production in glial cell, and in turn, alleviate neuronal injury.

ISSN 

1226-0487

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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