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Title 

VDUP1 is required for the development of natural killer cells

Authors 

Kee Nyung LeeH S KangJun Ho JeonE M KimSuk Ran YoonHyunKeun SongChil Youl LyuZ H PiaoSun-Uk KimY H HanS S SongY H LeeK S SongYong Man KimDae Yeul YuIn Pyo Choi

Publisher 

Elsevier (Cell Press)

Issue Date 

2005

Citation 

Immunity, vol. 22, no. 2, pp. 195-208

Keywords 

cell functioncell maturationnatural killer cellcell differentiationcell linekiller cells, natural

Abstract 

Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.

ISSN 

1074-7613

Link 

http://dx.doi.org/10.1016/j.immuni.2004.12.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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