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Title 

Varied patterns of DNA methylation change between different satellite regions in bovine preimplantation development

Authors 

Yong-Kook KangH J LeeJung Jae ShimSeungEun YeoSeok Ho KimDeog Bon KooKyung Kwang LeeZ BeyhanN L FirstYong Mahn Han

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

Molecular Reproduction and Development, vol. 71, no. 1, pp. 29-35

Keywords 

bovinedemethylationDNA methylationpreimplantation embryosatellite sequencessatellite DNAprenatal developmentDNA, satelliteembryonic developmentgene expression regulation, developmental

Abstract 

Global reduction of DNA methylation, a part of genome reprogramming processes, occurs in a gradual manner until before implantation and is recognized as a conserved process in mammals. Here, we reported that in bovine, satellite regions exhibited varied patterns of methylation changes when one-cell egg advanced to the blastocyst; a maintenance methylation was observed in satellite I sequences, a decrease in alpha satellites, and an increase in satellite II regions. Cloned embryos exhibited similar changes for DNA methylation in the satellite I and alpha. We also observed that the satellite I and α sequences were methylated more in inner cell mass region of the blastocyst whereas the satellite II showed selective demethylation in this region. Together, these findings point that individual satellite sequences carry their own methylation patterns under the pressure of global demethylation, suggesting that local methylation control system acts on the satellite regions in early bovine embryos.

ISSN 

1040-452X

Link 

http://dx.doi.org/10.1002/mrd.20249

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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