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Title 

Flavonoid compounds from Viola hondoensis and their effect on matrix metalloproteinase-1 in ultraviolet irradiation of cultured human skin fibroblasts

Authors 

H I MoonJoongku LeeO P ZeeJ H Chung

Publisher 

Springer Verlag (Germany)

Issue Date 

2005

Citation 

Food Science and Biotechnology, vol. 14, no. 1, pp. 143-146

Keywords 

viola hondoensismatrix metalloproteinase-1ultraviolet irradiationflavonoid

Abstract 

Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 2',4',7-trihydroxyisoflavone on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured human dermal fibroblasts. Phytochemical investigation of the whole plants of Viola hondoensis led to the isolation of five flavonoids. The structures of these compounds were identified 2',4',5,7-tetrahydroxyisoflavone (1), 2',4',7- trihydroxyisoflavone (2), 4',7-dihydroxyflavone (3), isoorientin (4), and isovitexin (5) using spectroscopic analysis. Among these, 2',4',7-trihydroxyisoflavone reduced the expression of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 2',4',7-trihydroxyisoflavone an important role in the reduction of MMP-1 induction by ultraviolet irradiation.

ISSN 

1226-7708

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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