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Title 

The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana

Authors 

N T DatX F CaiMun Chual RhoHyun Sun LeeK BaeY H Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 2, pp. 164-168

Keywords 

brachynereolidecorosolic acidcrepidiaside Cdiacylglycerol acyltransferasegermanicol acetateixerin Ymethyl ursolateyoungia koidzumianaacyltransferase

Abstract 

The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltrans-ferase (DGAT) from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of nine compounds, the structures of which were established using physicochemical and spectral data. of the isolated compounds, oleanolic acid (2), methyl ursolate (7) and corosolic aicd (8) inhibited DGAT, with IC50 values of 31.7, 26.4, and 44.3 μM, respectively. However, sesquiterpenoids showed only weak inhibitory effects toward DGAT.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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