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Title 

Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase

Authors 

Hyun Mi OhByoung-Mog KwonN I BaekS H KimI S ChungM H ParkH W ParkJ H LeeE J KimD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 2, pp. 169-171

Keywords 

FPTaseisorhamnetinpersicaria thunbergiifarnesyl trans transferasetransferasealkyl and aryl transferasesfarnesyltranstransferase

Abstract 

The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of isorhamnetin was 37.5 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02977709

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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