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Title 

Manassantin A and B isolated from Saururus chinensis inhibit TNF-α-induced cell adhesion molecule expression of human umbilical vein endothelial cells

Authors 

Oh Eok KwonHyun Sun LeeSeung Woong LeeMi Yeon ChungK H BaeMun Chual RhoYoung Kook Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 1, pp. 55-60

Keywords 

atherosclerosiscell adhesion moleculeshuman umbilical vein endothelial cellsmanassantin A/BmonocyteTNF-αcell adhesion moleculefuran derivativemanassantin Amanassantin B

Abstract 

Leukocyte adhesion to the vascular endothelium is a critical initiating step in inflammation and atherosclerosis. We have herein studied the effect of manassantin A (1) and B (2), dineolignans, on interaction of THP-1 monocytic cells and human umbilical vein endothelial cells (HUVEC) and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in HUVEC. When HUVEC were pretreated with 1 and 2 followed by stimulation with TNF-α, adhesion of THP-1 cells to HUVEC decreased in dose-dependent manner with IC50 values of 5 ng/mL and 7 ng/mL, respectively, without cytotoxicity. Also, 1 and 2 inhibited TNF-α-induced up-regulation of ICAM-1, VCAM-1 and E-selectin. The present findings suggest that 1 and 2 prevent monocyte adhesion to HUVEC through the inhibition of ICAM-1, VCAM-1 and E-selectin expression stimulated by TNF-α, and may imply their usefulness for the prevention of atherosclerosis relevant to endothelial activation.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02975136

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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