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Title 

Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng

Authors 

Mun Chual RhoHyun Sun LeeSeung Woong LeeJong Sun ChangOh Eok KwonMi Yeon ChungYoung Kook Kim

Publisher 

American Chemical Society

Issue Date 

2005

Citation 

Journal of Agricultural and Food Chemistry, vol. 53, no. 4, pp. 919-922

Keywords 

Acyl-CoAcholesterol acyltransferase (ACAT)atherosclerosischolesteryl esterpanax ginsengpolyacetylenescholesterol acyltransferase inhibitorginseng extractginsengenzyme inhibitors

Abstract 

Acyl-CoA: cholesterol acyltransferase (ACAT), which plays a role in the absorption, storage, and production of cholesterol, has been explored as a potential target for pharmacological intervention of hyperlipidemia and atherosclerotic disease. In our search for ACAT inhibitors from natural sources, the petroleum ether extract of Panax ginseng showed moderate inhibition of ACAT enzyme from rat liver microsomes. Bioactivity-guided fractionations led to the isolation of one new polyacetylenic compound, (9R,10S)-epoxy-16-heptadecene-4, 6-diyne-3-one (1), in addition to the previously reported polyacetylenic compounds 2 and 3. Their chemical structures were elucidated on the basis of spectroscopic evidence (UV, IR, NMR, and MS). The compounds 1, 2, and 3 showed significant ACAT inhibition with IC50 values of 35, 47, and 21 μM, respectively.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/jf040370x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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