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Title 

Multifunctional drug delivery system using starch-alginate beads for controlled release

Authors 

Young Joo KimH G ParkYoung Lyul YangY YoonSang Soo KimE Oh

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2005

Citation 

Biological & Pharmaceutical Bulletin, vol. 28, no. 2, pp. 394-397

Keywords 

alginate beadcoatingcontrolled releasedrug delivery systemstarchcontrolled drug releasedrug adsorptiondrug coatingdrug release

Abstract 

Utilizing starch-containing alginate beads, a novel drug delivery system (DDS) was developed. With the starch inside, the composite bead could be dried in its original bead shape and handled in the dried state. By employing alginate multi-coating strategy on the starch-alginate beads, detained or controlled release was efficiently achieved and successfully demonstrated for a model peptide drug, L-phenylalanine. The initial latent time and release rate of the drug inside the beads were able to be controlled simply by varying the number of multi-coatings. While the latent time for the initial release was negligible for non-coated starch-alginate beads, the latent times of beads coated one, two, and four times increased to 15, 30, and 70 min, respectively. Furthermore, the alginate component of the composite beads could adsorb and remove heavy metals such as lead from the body. These multifunctional beads combined with the novel coating process will greatly benefit alginate gel-based DDS.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.28.394

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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