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Title 

Hepatoprotective and antioxidant effects of Alnus japonica extracts on acetaminophen-induced hepatotoxicity in rats

Authors 

Sang Tae KimJ D KimS H AhnG S AhnYoung Ik LeeY S Jeong

Publisher 

Wiley-Blackwell

Issue Date 

2004

Citation 

Phytotherapy Research, vol. 18, no. 12, pp. 971-975

Keywords 

acetaminophenalnus japonicaantioxidantcytotoxicityfree radical scavengerhepatoprotectivealnus japonica extractplant extractantioxidant activitydrug effect

Abstract 

The stem bark of the Betulaceae plant Alnus japonica, which is indigenous to Korea, has been used as a popular folk medicine for hepatitis and cancer. In this study, the antioxidant activity of the crude extract and the hepatoprotective activities on acetaminophen (AAP)-induced toxicity in the rat liver were evaluated. We investigated the effect of the methanol (AJM) and solvent fracton of the stem bark of Alnus japonica (AJ) on AAP-induced hepatotoxicity in rats. In rat hepatocyte culture, pretreatment with AJM (50, 100, 150 and 200 μg/ml) significantly decreased the cytotoxicity of AAP in a dose-dependent manner. The pretreated with EtOAc and BuOH fraction led to an increase in free radical scavenging activity and a decrease in inhibition of lipid peroxidation, both superoxide dismutase and catalase prevent the hepatotoxicity by AAP in the treatment of A. japonica fraction. We conclude that AJ is an important antioxidant in AAP-induced live hepatotoxicity and that extract of AJM plays a hepatoprotective effects in the against AAP-induced cytotoxicity in cultured rat hepatocytes in vitro. Pending more evaluation for safety and efficacy, AJ can potentially be used in mitigating AAP-induced hepatotoxicity.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.1540

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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