상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis

Authors 

Seung Woong LeeHyun Sun LeeJung Yeon NamOh Eok KwonJin Ah BaekJong Sun ChangMun Chual RhoYoung Kook Kim

Publisher 

Elsevier

Issue Date 

2005

Citation 

Journal of Ethnopharmacology, vol. 97, no. 3, pp. 515-519

Keywords 

active-guided fractionationsCC chemokine receptor 2kurarinonemonocyte chemoattractant protein-1sophora flavescens aitmonocyte chemotactic protein 1sophora flavescens extractchemotaxissophora flavescens

Abstract 

The accumulation of circulating monocytes in the arterial wall is an early in atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) promotes the migration of monocytes and would play a role in the development of atherosclerotic lesions. Searching for inhibitors of MCP-1-induced cell migration from natural sources, we isolated one active compound through active-guided fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae). On the basis of spectral evidence, the structure of active compound was identified as kurarinone. It inhibited the migration of THP-1 cells induced by MCP-1 with IC50 value of 19.2 μg/mL. In addition, it inhibited the binding of MCP-1 to THP-1 cells and phosphorylation of p42/44 MARK.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2004.12.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)