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Title 

Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens

Authors 

Kwang Hee SonHyun Mi OhSung Kyu ChoiDong Cho HanByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2005

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 8, pp. 2019-2021

Keywords 

abietane diterpeneanti-tumorcancer cellabietane derivativesequoia sempervirens extractantineoplastic activitysequoiaantineoplastic agents, phytogeniccell line, tumorditerpenes, abietane

Abstract 

A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6α-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI 50 2-5 μg/mL.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2005.02.057

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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