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Title 

The effect of tiarellic acid on the expressions of matrix metalloproteinase-1 and type 1 procollagen in ultraviolet irradiated cultured human skin fibroblasts

Authors 

H I MoonJoongku LeeH C EunK H KimJ H Chung

Publisher 

Elsevier

Issue Date 

2005

Citation 

Journal of Ethnopharmacology, vol. 98, no. 1, pp. 185-189

Keywords 

MMP-1tiarellic acidtype 1- procollagenultraviolet irradiationcollagen type 1procollagen c proteinasedrug effecthumanhuman tissueprotein expression

Abstract 

Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of tiarellic acid on the expressions of MMP-1 and type 1 procollagen in ultraviolet irradiation of cultured human skin fibroblasts. Tiarellic acid reduced the expression of MMP-1 and induced the expression of type 1- procollagen at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that tiarellic acid plays an important role in the reduction of MMP-1 and induction of type 1- procollagen by ultraviolet irradiation.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2005.01.027

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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