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Title 

Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16

Authors 

Hee Gu LeeKyung Ae YuWon Keun OhTae Woong BaegH C OhJong Seog AhnW C JangJong Wan KimJ S LimYong Kyung ChoeDo Young Yoon

Publisher 

Elsevier

Issue Date 

2005

Citation 

Journal of Ethnopharmacology, vol. 98, no. 3, pp. 339-343

Keywords 

artermisia argyicervical cancerE6E7HPVjaceosidinartemisia arygyi extractartemisiahuman papillomavirus type 16protein function

Abstract 

Jaceosidin (4′,5,7-trihydroxy-3′,6-dimethoxyflavone) was isolated from Artemisia argyi as a putative oncogene inhibitor. Jaceosidin inhibited binding between oncoprotein E6 of the human papillomavirus and the p53 tumor suppressor protein. In addition, jaceosidin inhibited binding between the E7 oncoprotein and the Rb tumor suppressor protein, and also inhibited the function of HPV-16 harboring cervical cancer cells, including SiHa and CaSki. Collectively, jaceosidin inhibited the functions of the E6 and E7 oncoproteins of the human papillomavirus, suggesting that this compound might be used as a potential drug for the treatment of cervical cancers associated with the human papillomavirus.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2005.01.054

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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