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Title 

Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1

Authors 

Ai Guo WangS B SeoH B MoonH J SHinD H KimJ M KimT H LeeH J KwonDae Yeul YuDong Seok Lee

Publisher 

Elsevier

Issue Date 

2005

Citation 

Biochemical and Biophysical Research Communications, vol. 330, no. 2, pp. 461-466

Keywords 

histone deacetylase 1nuclear pleomorphismp21p53steatosiscyclin dependent kinase inhibitor 1mousenonhumantransgenic mouse

Abstract 

It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2005.02.179

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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