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Title 

Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes

Authors 

J Y LeeS S MoonBong Sik YunIck Dong YooB K Hwang

Publisher 

American Chemical Society

Issue Date 

2004

Citation 

Journal of Natural Products, vol. 67, no. 12, pp. 2076-2078

Keywords 

antibiotic agentantifungal agentbutyric acidthiobutacinunclassified drugactinobacteriaantifungal activitybotrytis cinereadrug isolationlechevalieria aerocolonigenes

Abstract 

A novel butanoic acid, thiobutacin (1), 4-(2-aminophenyl)-4-oxo-2- methylthiobutanoic acid (C11H13NO3S), was isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9. The structure of thiobutacin (1) was elucidated on the basis of the extensive 2D NMR spectral data including 1H- 1H COSY, HMBC, HMQC, ROESY, and NOESY. Thiobutacin (1) showed antioomycete and antifungal activity against phytopathogenic Phytophthora capsici and Botrytis cinerea and the yeast Saccharomyces cerevisiae.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np049786v

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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