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Title 

The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

Authors 

Y YangJeong-Hyung LeeKun Yong KimH K SongJae Kwang KimSuk Ran YoonD ChoK S SongY H LeeIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2005

Citation 

Cancer Letters, vol. 221, no. 2, pp. 191-200

Keywords 

9-27IFN-γinvasionnatural killer cellgamma interferongamma interferon inducible protein 9-27animal cellcancer cellcancer cell culturecancer invasion

Abstract 

As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.

ISSN 

0304-3835

Link 

http://dx.doi.org/10.1016/j.canlet.2004.08.022

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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