상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

Authors 

Soo Jin ChooH R ParkIn Ja RyooJong Pyung KimBong Sik YunChang-Jin KimK Shin-yaIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2005

Citation 

Journal of Antibiotics, vol. 58, no. 3, pp. 210-213

Keywords 

anticancer agentsdeoxyverrucosidinglucose-regulated protein 78 (GRP78)penicillium sp.glucose regulated protein 78luciferaseunclassified drugcarbon nuclear magnetic resonancedose response

Abstract 

Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC 50 of 30 nM.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)