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Title 

Isolation of sangivamycin from Streptomyces sp. A6497 and its herbicidal activity

Authors 

E I HwangBong Sik YunS W ChoiJ S KimS J LimJae Sun MoonS H LeeSung Uk Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2005

Citation 

Journal of Microbiology and Biotechnology, vol. 15, no. 2, pp. 434-437

Keywords 

chemotaxonomyherbicidal activitysangivamycinselective screeningantifungal activitydrug isolationmass spectrometerstreptomycesstructure activity relationultraviolet spectrophotometry

Abstract 

During the screening for the inhibitors of cellulose biosynthesis as herbicides, we discovered a Streptomyces sp. A6497 with a selective antifungal activity against cellulose containing Phytophthora parasitica, but not against cellulose lacking Candida albicans. The inhibitor was isolated and identified, using a series of chromatographies. Based on structure analyses with UV spectrophotometry, mass and various NMR, the inhibitor was identified as sangivamycin. The compound exhibited strong antifungal activities against P. parasitica (MIC; 3.125 μg/ml). In particular, it showed strong herbicidal activities against various weeds in the greenhouse experiment. Taken together, these results suggest that sangivamycin is a useful lead compound for the development of new herbicides.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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