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Title 

Structures and biological activities of novel antibiotic peptaibols neoatroviridins A - D from Trichoderma atroviride F80317

Authors 

Seung Uk OhBong Sik YunS J LeeIck Dong Yoo

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2005

Citation 

Journal of Microbiology and Biotechnology, vol. 15, no. 2, pp. 384-387

Keywords 

membrane-perturbing activityneoatroviridinspeptaibol antibioticstructure determinationtrichoderma atroviride2 amino 2 methylpropionic acidacid hydrolasealamethicinantibiotic agentisovaline

Abstract 

Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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