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Title 

Requirement of the receiver and phosphotransfer domains of ArcB for efficient dephosphorylation of phosphorylated ArcA in vivo

Authors 

G R Pena-SandovalOh Suk KwonD Georgellis

Publisher 

American Society for Microbiology

Issue Date 

2005

Citation 

Journal of Bacteriology, vol. 187, no. 9, pp. 3267-3272

Keywords 

phosphotransferasein vivo studyprotein dephosphorylationprotein domainarca

Abstract 

The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory conditions of growth. Under anoxic growth conditions, ArcB autophosphorylates and transphosphorylates ArcA, which in turn represses or activates its target operons. Under aerobic growth conditions, phosphorylated ArcA (ArcA-P) dephosphorylates and its transcriptional regulation is released. The dephosphorylation of ArcA-P has been shown to occur, at least in vitro, via an ArcAAsp54-P → ArcBHis717-P → ArcB Asp576-P → Pi reverse phosphorelay. In this study, the physiological significance of this pathway was assessed. The results demonstrate that the receiver and phosphotransfer domains of the tripartite sensor kinase ArcB are necessary and sufficient for efficient ArcA-P dephosphorylation in vivo.

ISSN 

0021-9193

Link 

http://dx.doi.org/10.1128/JB.187.9.3267-3272.2005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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