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Title 

A novel function of benzyl isothiocyanate in vascular smooth muscle cells: The role of ERK1/2, cell cycle regulation, and matrix metalloproteinase-9

Authors 

J Y LeeS K MoonC W HwangK S NamY K KimH D YoonMin-Gon KimC H Kim

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

Journal of Cellular Physiology, vol. 203, no. 3, pp. 493-500

Keywords 

benzyl isothiocyanategelatinase Bimmunoglobulin enhancer binding proteinmitogen activated protein kinase 1mitogen activated protein kinase 3transcription factor AP 1tumor necrosis factor alphacell cycle G1 phasecell cycle S phaseconcentration response

Abstract 

Dietary isothiocyanates (ITCs) have shown protective effects against certain chemically induced cancers in animal models. These inhibitory effects are associated with reduced levels of extracellular signal-regulated kinase (ERK) 1/2 activity and the arrest of the G1 cell cycle. Benzyl isothiocyanate (BITC) treatment down-regulates cyclins and CDKs and up-regulates the expression of the CDK inhibitor p21, but up-regulation of p27 or p53 was not detected. Since antiatherogenic effects are not needed for antiproliferation, we determined whether BITC exerted inhibitory effects on matrix metalloproteinase-9(MMP-9) activity in TNF-α-induced vascular smooth muscle cells (VSMCs). BITC inhibited TNF-α-induced MMP-9 secretion in VSMC in a dose dependent manner. This inhibition was characterized by the down-regulation of MMP-9, which is transcriptionally regulated at the NF-κB site, and the activation protein-1 (AP-1) site in the MMP-9 promoter. These findings indicate that BITC is an effective agent for inhibiting cell proliferation, the G1 to S phase cell cycle progress, and MMP-9 expression through the transcription factors NF-κB and AP-1 in TNF-α-induced VSMC.

ISSN 

0021-9541

Link 

http://dx.doi.org/10.1002/jcp.20257

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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