상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Isoflavonoid from Viola hondoensis, regulates the expression of matrix metalloproteinase-1 in human skin fibroblasts

Authors 

H I MoonJoongku LeeJ H KwakO P ZeeJ H Chung

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2005

Citation 

Biological & Pharmaceutical Bulletin, vol. 28, no. 5, pp. 925-928

Keywords 

2′,4′,7-hydroxyisoflavonehuman skin fibroblastsmatrix metalloproteinase (MMP)-1MMP-2viola hondoensisisoflavonoidviola hondoensis extracthumanhuman cellprotein expression

Abstract 

Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of 2′,4′,7-trihydroxyisoflavone isolated from the whole plants of Viola hondoensis (Violaceae) on the expression of MMPs in UV-irradiated human skin fibroblasts in vitro. 2′,4′,7-Trihydroxyisoflavone markedly reduced UV-induced MMP-1 expression, but not MMP-2, at the both mRNA and protein levels in a dose-dependent manner. Our report is the first description for the ability of 2′,4′,7-trihydroxyisoflavone to regulate MMP-1 expression specifically.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.28.925

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


Files in This Item: SizeFormat
5925.pdf370KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)