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Title 

Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent

Authors 

D H KimS J JungI S ChungY H LeeD K KimS H KimByoung-Mog KwonTae Sook JeongM H ParkN S SeoungN I Baek

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 5, pp. 541-545

Keywords 

compositaeergosterol peroxideerigeron annuus L.haCAT1 inhibitory effectLp-PLA2 inhibitory effectcholesterolcholesterol acyltransferaseergosterolergosterol 5,8 peroxideergosterol-5,8-peroxide

Abstract 

Flowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activityguided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant. This compound exhibited hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 ± 0.9 and 51.7 ± 1.2%, at a treatment concentration of 0.23 mM.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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