상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines

Authors 

Y S KimJ S KimS U ChoiHyun Sun LeeS H RohY C JeongY K KimS Y Ryu

Publisher 

Georg Thieme Verlag

Issue Date 

2005

Citation 

Planta Medica, vol. 71, no. 6, pp. 566-568

Keywords 

deapioplatycodin ddeapioplatycodin d 3deapioplatycoside eplatycodinplatycodin d 2platycodin d 3platycoside Epolygalacin d 2saponinunclassified drug

Abstract 

A novel triterpenoid saponin, deapioplatycoside E (1) was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2-8, i.e., platycoside E (2), deapioplatycodin D3 (3), platycodin D3 (4), polygalacin D2 (5), platycodin D2 (6), deapioplatycodin D (7) and platycodin D (8). The structure of the new saponin 1 was determined on the basis of spectral analysis and chemical evidence. The crude saponin fraction (ED50: ca. 10-15 μg/mL) and compounds 6-8 (ED50: ca. 4-18 μg/mL) exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i.e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2005-864161

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)