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Title 

Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots

Authors 

Woo Song LeeM J KimY I BeckY D ParkTae Sook Jeong

Publisher 

Elsevier

Issue Date 

2005

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 15, pp. 3573-3575

Keywords 

fatty acid glycerolsLp-PLA2 inhibitorsaururus chinensisacetic acid ethyl esterfatty acid derivativeglycerol derivativeglycerol monolinoleateglycerol stearatesaururus chinensis extractacylglycerol

Abstract 

(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA 2. The (R)-4 and (S)-4 exhibited Lp-PLA2 inhibitory activities with IC50 values of 45.0 and 52.0 μM, respectively.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2005.05.056

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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