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Title 

Coumarins and chromones from Angelica genuflexa

Authors 

Ren Bo AnBo Young ParkJung Hee KimOk Kyoung KwonJoongku LeeByung Sun MinKyung Seop AhnSei Ryang OhHyeong Kyu Lee

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2005

Citation 

Natural Products Sciences, vol. 11, no. 2, pp. 79-84

Keywords 

angelica genuflexaanticomplement activitydemethylsuberosinhamaudolheracleninprim-O-glucosylcimifuginsec-O-glucosylhamaudolumbelliferonecoumarin derivativeangelica

Abstract 

Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gel column chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin (4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and four chromones, hamaudol (6), cimifugin (10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), were identified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 were isolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examined for their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an IC50 value of 390 μM.

ISSN 

1226-3907

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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