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Title 

Flavonoids from the leaves of Litsea japonica and their anti-complement activity

Authors 

Sun Young LeeByung Sun MinJung Hee KimJoongku LeeT J KimC S KimY H KimHyeong Kyu Lee

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

Phytotherapy Research, vol. 19, no. 4, pp. 273-276

Keywords 

afzelinanti-complement activitylitsea japonicaquercetintilirosideflavonoidlitsea japonica extractcomplement systemdrug activitylitsea

Abstract 

Four flavonoids, epicatechin (1), afzelin (2), quercitrin (3), and tiliroside (4), were isolated from the leaves of Litsea japonica (Thunb.) Jussieu (Lauraceae). The structures of compounds were identified by comparing their chemical and spectral data with those previously reported. The flavonoids (1-4) were tested for their anti-complement activity against classical pathway of complement system. Compounds 2-4 showed inhibitory activity against complement system with IC50 values of 258, 440, and 101 μM, respectively, whereas 1 was inactive. For the evaluation of the structure-activity relationship of 5,7-dihydroxyflavones, myricitrin (5) from Juglans mandshurica also tested for it's anti-complement activity and is inactive in this assay system. Furthermore, compounds 2,3, and 5 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (5a), and these were also tested for their activity. of the three aglycones, 2a exhibited anticomplement activity with an IC50 value of 730 μM, while 3a and 5a were inactive. The inhibitory potencies of 2, 2a, 3, 3a, 5, and 5a against complement activity increased in inverse proportion to number of free hydroxyls on B-ring of 5,7-dihydroxyflavone. of the compounds tested, 4 showed the most potent inhibitory activity against the complement system.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.1453

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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