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Title 

Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos

 

Asparagus oligoclonos의 뿌리로부터 분리한 세포독성활성을 나타내는 스테로이드사포닌

Authors 

G S KimH T KimJ D SeongSei Ryang OhC O LeeJ K BangN S SeongK S Song

Publisher 

American Chemical Society

Issue Date 

2005

Citation 

Journal of Natural Products, vol. 68, no. 5, pp. 766-768

Keywords 

cytotoxic agentasparagusasparagus oligoclonosdrug cytotoxicityrhizomeasparagus plantsaponins

Abstract 

Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5β-spirostan-3β,17α-diol 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside and (25S*)-5β-spirostan-3β,17α-diol 3-O-α-L- rhamnopyanosyl (1→4)-[β-D-xylopyranosyl-(1→2)]-β-D- glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 μg/mL.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np040128k

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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