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Title 

A combined approach for locating Box H/ACA snoRNAs in the human genome

Authors 

H S EoK S JoS W LeeChang-Bae KimW Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2005

Citation 

Molecules and Cells, vol. 20, no. 1, pp. 35-42

Keywords 

Box H/ACA snoRNAhidden markov modelminimum free energyDEAD box proteininitiation factornuclear proteinnucleic acid binding proteinsmall nucleolar RNAamino acid sequencecomputer program

Abstract 

A novel combined method for locating box H/ACA small nucleolar RNAs (snoRNAs) is described, together with a software tool. The method adopts both a probabilistic hidden Markov model (HMM) and a minimum free energy (MFE) rule, and filters possible candidate box H/ACA snoRNAs obtained from genomic DNA sequences. With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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