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Title 

PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza

 

단삼에서 분리한 diterpene abietane 화합물의 PTP1b 저해활성

Authors 

Yu Mi HanH OhMinKyun NaB S KimWon Keun OhBo Yeon KimDae Gwin JeongSeong Eon RyuD E SokJong Seog Ahn

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2005

Citation 

Biological & Pharmaceutical Bulletin, vol. 28, no. 9, pp. 1795-1797

Keywords 

dihydroisotanshinone Iisocryptotanshinoneisotanshinone IIAlabiataeprotein tyrosine phosphatase 1B (PTP1B) inhibitorsalvia miltiorrhizaabietane derivativedrug effectsalviaditerpenes, abietane

Abstract 

Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μM, 22.4±0.6 μM and 56.1±6.3 μM, respectively.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.28.1795

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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