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Title 

Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction

 

하이드록시아이소유레아의 분해효소인 트란스싸이렉틴유사 단백질들

Authors 

You Ra LeeDo Hee LeeChang Won KhoAh Young LeeMi JangS ChoChoong Hwan LeeJong Suk LeeP K MyungByoung Chul ParkSung Goo Park

Publisher 

Elsevier

Issue Date 

2005

Citation 

FEBS Letters, vol. 579, no. 21, pp. 4769-4774

Keywords 

hydroxyisouratePucMtransthyretin-related proteinsuric aciduricase5 hydroxyisouratehydroxyisourate hydrolasepucm proteinhydrolysisprotein functionbacterial proteins

Abstract 

Purine catabolic pathway in Bacillus subtilis is consisted of more than 14 genes. Among these genes, pucL and pucM are required for uricase activity. While PucL is known to encode the uricase itself, the function of PucM is still unclear although this protein is also indispensable for uric acid decomposition. Here, we provide evidence that PucM, a transthyretin-related protein, functions to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Based on these results, we propose that transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as a hydroxyisourate hydrolase.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2005.07.056

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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