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Title 

Quantitative trait Loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model

Authors 

E H KimChul Ho LeeByung Hwa HyunJ G SuhY S OhT NamikawaA Ishikawa

Publisher 

Japanese Association for Laboratory Animal Sciences

Issue Date 

2005

Citation 

Experimental Animals, vol. 54, no. 4, pp. 319-325

Keywords 

body weightfocal glomerulosclerosiskidney weightmousequantitative trait locusanimal modelkidney massmouse strainquantitative trait locus mapping

Abstract 

In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance.

ISSN 

1341-1357

Link 

http://dx.doi.org/10.1538/expanim.54.319

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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