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Title 

Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells

 

하드록시 신남알데하이드에서 유고되는

Authors 

S H LeeC W LeeJ W LeeM S ChoiD J SonY B ChungC K LeeK W OhD C MoonByoung-Mog KwonJ T Hong

Publisher 

Elsevier

Issue Date 

2005

Citation 

Biochemical Pharmacology, vol. 70, no. 8, pp. 1147-1157

Keywords 

2′-Hydroxycinnamaldehydeapoptotic cell deathcolon cancerERKNF-κB2' hydroxycinnamaldehydeimmunoglobulin enhancer binding proteinprotein Baxprotein bcl 2cancer cell culture

Abstract 

2′-Hydroxycinnamaldehyde (HCA) inhibits cell growth of several human cancer cells with unknown mechanisms. We investigated the inhibitory effect of HCA on TNF-α-induced cell growth and possible signal pathway in SW620 colon cancer cells. HCA inhibited TNF-α-induced SW620 colon cell growth in time- and dose-dependent manner through induction of apoptotic cell death. Parallel with inhibitory effect on cell growth, HCA dose dependency inhibited TNF-α-induced activation of NF-κB accompanied with inhibition of the translocation of p50. HCA also induced expression of caspase-3 and Bax, but decreased Bcl-2. HCA furthermore activated ERK pathway, and ERK inhibitor reversed inhibitory effect of HCA on cell growth and transcriptional activation of NF-κB. These results demonstrate that HCA inhibits cell growth through induction of apoptotic cell death by ERK pathway-dependent NF-κB inactivation.

ISSN 

0006-2952

Link 

http://dx.doi.org/10.1016/j.bcp.2005.07.028

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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