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Title 

Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids

Authors 

Chang Ji ZhengJung Sung YooT G LeeH Y ChoY H KimWon Gon Kim

Publisher 

Elsevier

Issue Date 

2005

Citation 

FEBS Letters, vol. 579, no. 23, pp. 5157-5162

Keywords 

antibacterialenoyl-acyl carrier protein reductasefatty acid synthesislinoleic acidunsaturated fatty acidacetic acidarachidonic acidbacterial enzymelong chain fatty acidoleic acid

Abstract 

Long-chain unsaturated fatty acids, such as linoleic acid, show antibacterial activity and are the key ingredients of antimicrobial food additives and some antibacterial herbs. However, the precise mechanism for this antimicrobial activity remains unclear. We found that linoleic acid inhibited bacterial enoyl-acyl carrier protein reductase (FabI), an essential component of bacterial fatty acid synthesis, which has served as a promising target for antibacterial drugs. Additional unsaturated fatty acids including palmitoleic acid, oleic acid, linolenic acid, and arachidonic acid also exhibited the inhibition of FabI. However, neither the saturated form (stearic acid) nor the methyl ester of linoleic acid inhibited FabI. These FabI-inhibitory activities of various fatty acids and their derivatives very well correlated with the inhibition of fatty acid biosynthesis using [14C] acetate incorporation assay, and importantly, also correlated with antibacterial activity. Furthermore, the supplementation with exogenous fatty acids reversed the antibacterial effect of linoleic acid, which showing that it target fatty acid synthesis. Our data demonstrate for the first time that the antibacterial action of unsaturated fatty acids is mediated by the inhibition of fatty acid synthesis.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2005.08.028

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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