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Title 

The effect of flavonol glycoside on the expressions of matrix metalloproteinase-1 in ultraviolet-irradiated cultured human skin fibroblasts

Authors 

H I MoonJoongku LeeO P ZeeJ H Chung

Publisher 

Elsevier

Issue Date 

2005

Citation 

Journal of Ethnopharmacology, vol. 101, no. 1, pp. 176-179

Keywords 

MMP-1quercetin-3-O-β-d-(6″-feruloyl)- galactopyranosideultravioletviola hondoensisflavonoid glycosidedrug effecthumanhuman cellhuman cell cultureprotein expression

Abstract 

Long-term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases, such as skin cancer as well as photo-aging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here, we investigated the effect of quercetin-3-O-β-d-(6″-feruloyl)-galactopyranoside isolated from the stems of Viola hondoensis (Violaceae) on the expression of MMPs in UV-irradiated human skin fibroblasts in vitro. Quercetin-3-O-β-d-(6″-feruloyl)- galactopyranoside markedly reduced UV-induced MMP-1 expression at the protein levels in a dose-dependent manner. Our report is the first description for the ability of quercetin-3-O-β-d-(6″-feruloyl)-galactopyranoside to regulate UV-induced MMP-1 expression.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2005.04.032

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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