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Title 

Histone deacetylase 1 contributes to cell cycle and apoptosis

Authors 

Ai Guo WangSun-Uk KimS H LeeS K KimS B SeoDae Yeul YuDong Seok Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2005

Citation 

Biological & Pharmaceutical Bulletin, vol. 28, no. 10, pp. 1966-1970

Keywords 

apoptosiscell cyclehistone deacetylase 1steatosisprotein p21cyclin-dependent kinase inhibitor p21histone deacetylases

Abstract 

Histone deacetylases (HDACs) are generally thought to play important roles in human disease. However, little information is available concerning the specific functions of individual HDACs. We previously reported on transgenic mice that expressed human HDAC1 and experienced steatosis and nuclear pleomorphism in their hepatic tissues. To find out if the over-expression of HDAC1 contributes to the expression of genes related to the cell cycle, apoptosis, and lipid metabolism that eventually contribute to the pathological changes in the livers of the transgenic mice, the expression profiles of the related genes in liver tissues were determined by reverse transcription- polymerase chain reaction (RT-PCR) and Western blot analysis. The activated human HDAC1 significantly induced the expression levels of mRNA for p53, PPAR-gamma and Bak and reduced the p21 expression level compared with the levels in control littermates. However, the protein levels of p53 and PPAR-gamma were significantly decreased. In conclusion, our results indicate that HDAC1 can regulate gene expression at the mRNA and protein levels independently and that this may be a potential cytopathic factor for hepatic tissue in transgenic mice that over-express HDAC1.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.28.1966

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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