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Title 

Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis

 

Hovenia dulcis로부터 분리한 phenolic compounds의 neuroprotective와 free radical scavenging activities

Authors 

Gao LiB S MinC ZhengJoongku LeeSei Ryang OhKyung Seop AhnHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 7, pp. 804-809

Keywords 

(+)-Afzelechin(-)-CatechinABTSDPPHhovenia dulcisHT22 cellsneuroprotectionsuperoxideneuroprotective agentfree radical scavengers

Abstract 

The EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an IC50 value of 57.7 μM, and a superoxide anion radical scavenging effect with an IC50 value of 8.0 μM. Both compounds 6 and 8 had ABTS cation radical scavenging effects with IC50 values of 7.8 μM and 23.7 μM, respectively. These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02977346

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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