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Title 

Activity of some aminoglycoside antibiotics against true fungi, Phytophthora and Pythium species

Authors 

H B LeeY KimJ C KimG J ChoiS H ParkChang-Jin KimH S Jung

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

Journal of Applied Microbiology, vol. 99, no. 4, pp. 836-843

Keywords 

aminoglycoside antibioticsantifungal activityantioomycete activitybiocontrol agentoomycetesstreptomyces sp. AMG-P1aminoglycosideaminoglycoside antibiotic agentantibioticsfungus

Abstract 

Aims: To investigate the in vitro antifungal and antioomycete activities of some aminoglycosides against true fungi and Phytophthora and Pythium species and to evaluate the potential of the antibiotics against Phytophthora late blight on plants. Methods and Results: Antifungal and antioomycete activities of aminoglycoside antibiotics (neomycin, paromomycin, ribostamycin and streptomycin) and a paromomycin-producing strain (Streptomyces sp. AMG-P1) against Phytophthora and Pythium species and 10 common fungi were measured in potato dextrose broth (PDB) and on seedlings in pots. Paromomycin was the most active against Phytophthora and Pythium species with a minimal inhibitory concentration of 1-10 μg ml-1 in PDB, but displayed low to moderate activities towards other common fungi at the same concentration. Paromomycin also showed potent in vivo activity against red pepper and tomato late blight diseases with 80 and 99% control value, respectively, at 100 μg ml-1. In addition, culture broth of Streptomyces sp. AMG-P1 as a paromomycin producer exhibited high in vivo activity against late blight at 500 μg freeze-dried weight per millilitre. Conclusions: Among tested aminoglycoside antibiotics, paromomycin was the most active against oomycetes both in vitro and in vivo. Significance and Impact of the Study: Data from this study show that aminoglycoside antibiotics have in vitro and in vivo activities against oomycetes, suggesting that Streptomyces sp. AMG-P1 may be used as a biocontrol agent against oomycete diseases.

ISSN 

1364-5072

Link 

http://dx.doi.org/10.1111/j.1365-2672.2005.02684.x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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