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Title 

A practical enzymatic synthesis of UDP sugars and NDP glucoses

Authors 

JungDon BaeKwang Ho KimDooIl KimYongseok ChoiJoong Su KimSukhoon KohS I HongDae Sil Lee

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

ChemBioChem, vol. 6, no. 11, pp. 1963-1966

Keywords 

enzyme catalysisglycosyltransferasesnucleotide sugarsthermus caldophilusglucose 1 phosphateglucose derivativeglycosyltransferasenucleoside diphosphate sugarphosphorylaserecombinant enzyme

Abstract 

Mix and match. Nucleotide sugars are essential as glycoside donors to glycosyltransferases for the synthesis of bioactive metabolites. With 45 combinations of reactions with five NTPs and nine sugar-1-phosphates (Su1Ps) by recombinant UDP-sugar pyrophosphorylase (Up) from Thermus caldophilus GK24, the enzyme showed broad substrate specificity toward five types of NTP with glucose-1-phosphate as well as four Su1Ps with UTP, affording all nine nucleotide sugars.

ISSN 

1439-4227

Link 

http://dx.doi.org/10.1002/cbic.200500183

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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