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Title 

Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A

 

프로디지오신의 GVHD 치료효과

Authors 

Sang Bae HanChang Woo LeeYeo Dae YoonJong Soon KangKi Hoon LeeWoon Kee YoonYoung Kook KimKiho LeeSong Kyu ParkHwan Mook Kim

Publisher 

Elsevier

Issue Date 

2005

Citation 

Biochemical Pharmacology, vol. 70, no. 10, pp. 1518-1526

Keywords 

cyclosporin Agraft-versus-host diseaseprodigiosininterleukin 2 receptor alphaacute graft versus host diseaseanimal modelcell proliferationdrug efficacyfemale

Abstract 

Prodigiosin (PDG), a bacterial metabolite, is a known T cell-specific immunosuppressant. Here, we compared its inhibitory potency and mode of action with cyclosporine A (CsA) in a mouse model. PDG efficiently inhibited T cell proliferation with an IC50 of 3.37 ng/ml, a similar dose to that of CsA (IC50 of 2.71 ng/ml). PDG inhibited only IL-2Rα expression, but not IL-2 expression, whereas CsA inhibited both. Exogenously added IL-2 reversed the suppressive activity of CsA, but not that of PDG. Moreover, although both PDG and CsA markedly reduced mortality rates in lethal acute graft-versus-host disease (GVHD), the combined treatment was more effective than either drug alone. These results demonstrate that PDG and CsA have similar inhibitory potencies, but different modes of action, and suggest that PDG has potential use as a supplementary immunosuppressant in combination with CsA for the treatment of GVHD.

ISSN 

0006-2952

Link 

http://dx.doi.org/10.1016/j.bcp.2005.08.017

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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