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Title 

Effect of kikkanol F monoacetate and 5-hydroxy-6,7,3',4'-tetramethoxyflavone isolated from Chrysanthemum indicum L. on IL-6 production

 

감국에서 분리한 kikkanol F monoacetate와 5-Hydroxy-6,7,3',4'-tetramethoxyflavone의 IL-6 생성억제활성

Authors 

Jung Yeon NamHyun Sun LeeSeung Woong LeeMi Yeon ChungJ H ChoiE S YooMun Chual RhoYoung Kook Kim

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2005

Citation 

Korean Journal of Pharmacognosy, vol. 36, no. 3, pp. 186-190

Keywords 

5-hydroxy-6, 7, 3′, 4′-tetramethoxyflavonechrysanthemum indicum L.IL-6kikkanol F monoacetateRAW264.7 cells5 hydroxy 6,7,3',4' tetramethoxyflavonechrysanthemum extractinterleukin 6lipopolysaccharideunclassified drug

Abstract 

Searching for inhibitors of lipopolysaccharide (LPS)-induced IL-6 (Interleukin-6) production from medicinal herbs, we isolated two active compounds through bioactivity-guided fractionation from the methanol extract of Chrysanthemum indicum L.. They were determined as kikkanol F monoacetate (1) and 5-hydroxy-6, 7, 3′, 4′-tetramethoxyflavone (2) by means of spectroscopy techniques such as NMR and MS. The compound 1 and 2 inhibited LPS-induced IL-6 production in the RAW264.7 cells with IC50 value of 47 μg/ml and 27 μg/ml, respectively.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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