상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation

Authors 

S M LeeJ W LeeY S SongD Y HwangY K KimS Y NamD J KimY W YunDo Young YoonJ T Hong

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

Journal of Neuroscience Research, vol. 82, no. 4, pp. 542-550

Keywords 

calciumcell differentiationpresenilin 2ryanodine receptorreceptor blocking agentanimal cellcalcium cell levelmutationnerve cell differentiationcells, cultured

Abstract 

Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular calcium levels. Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation. Our results indicate that mutant PS2 inhibits normal neuronal cell differentiation and that RyR-mediated calcium overrelease may be a significant factor.

ISSN 

0360-4012

Link 

http://dx.doi.org/10.1002/jnr.20655

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)