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Title 

Signaling pathways implicated in α-melanocyte stimulating hormone-induced lipolysis in 3T3-L1 adipocytes

Authors 

Kyung Joo ChoJung Hyun ShimMin Chul ChoYong Kyung ChoeJ T HongD C MoonJ W KimDo Young Yoon

Publisher 

Wiley-Blackwell

Issue Date 

2005

Citation 

Journal of Cellular Biochemistry, vol. 96, no. 4, pp. 869-878

Keywords 

ACTHadipocytehormone-sensitive lipaselipolysismelanocortinsMSHhormone sensitive lipasecell strain 3T3hormone action3T3-L1 cells

Abstract 

Melanocortins, besides their central roles, have also recently been reported to regulate adipocyte metabolism. In this study, we attempted to characterize the mechanism underlying α-melanocyte-stimulating hormone (MSH)-induced lipolysis, and compared it with that of the adrenocorticotrophin hormone (ACTH) in 3T3-L1 adipocytes. Similar to ACTH, MSH treatment resulted in the release of glycerol into the cell supernatant. The activity of hormone-sensitive lipase, a rate-limiting enzyme, which is involved in lipolysis, was significantly increased by MSH treatment. In addition, a variety of kinases, including protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) were also phosphorylated as the result of MSH treatment, and their specific inhibitors caused a reduction in MSH-induced glycerol release and HSL activity, indicating that MSH-induced lipolysis was mediated by these kinases. These results suggest that PKA and ERK constitute the principal signaling pathways implicated in the MSH-induced lipolytic process via the regulation of HSL in 3T3-L1 adipocytes.

ISSN 

0730-2312

Link 

http://dx.doi.org/10.1002/jcb.20561

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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