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Title 

Stage-dependent gene expression profiles during natural killer cell development

Authors 

H S KangE M KimS LeeSuk Ran YoonT KawamuraYoung Cheol LeeS KimP K MyungS M WangIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2005

Citation 

Genomics, vol. 86, no. 5, pp. 551-565

Keywords 

developmentLPLNK cellsSAGEanimal cellcell culturecell maturationdevelopmental stagegene expression profilinggene identification

Abstract 

Natural killer (NK) cells develop from hematopoietic stem cells (HSCs) in the bone marrow. To understand the molecular regulation of NK cell development, serial analysis of gene expression (SAGE) was applied to HSCs, NK precursor (pNK) cells, and mature NK cells (mNK) cultured without or with OP9 stromal cells. From 170,464 total individual tags from four SAGE libraries, 35,385 unique genes were identified. A set of genes was expressed in a stage-specific manner: 15 genes in HSCs, 30 genes in pNK cells, and 27 genes in mNK cells. Among them, lipoprotein lipase induced NK cell maturation and cytotoxic activity. Identification of genome-wide profiles of gene expression in different stages of NK cell development affords us a fundamental basis for defining the molecular network during NK cell development.

ISSN 

0888-7543

Link 

http://dx.doi.org/10.1016/j.ygeno.2005.06.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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